Fludarabine Phosphate (Fludara)

Product Name:	Fludarabine Phosphate (Fludara)
CAT#:	DEJ-2312-LGZ-6
Package:	10mg/50mg/100mg/10mM * 1mL in DMSO
Datasheet

Description

Fludarabine or fludarabine phosphate (Fludara) is a chemotherapy drug used to treat hematological malignancies (cancers of blood cells such as leukemia and lymphoma). Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. It is active on both dividing and resting cells.

Basic Information

CAS Number:	75607-67-9
Formula:	C10H13FN5O7P
Molecular Weight:	365.2
SMILES:	O[C@H]1[C@H](O)[C@H](O[C@H]1n1cnc2c1nc(F)nc2N)COP(=O)(O)O
*Solubility-In vitro:*	In vitro (25°C): DMSO: 66 mg/mL (180.71 mM) Water: Warmed: 2 mg/mL (5.47 mM) Ethanol: Insoluble
*Solubility-In vivo:*	30% propylene glycol, 5% Tween 80, 65% D5W: 28 mg/mL

Target Info

DNA polymerase α:	1.1 μM(Ki )
DNA polymerase δ:	1.3 μM(Ki)

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 27.38 mL 0.1 mM_5 mg: 136.91 mL 0.1 mM_10 mg: 273.82 mL 0.5 mM_1 mg: 5.48 mL 0.5 mM_5 mg: 27.38 mL 0.5 mM_10 mg: 54.76 mL 1 mM_1 mg: 2.74 mL 1 mM_5 mg: 13.69 mL 1 mM_10 mg: 27.38 mL 5 mM_1 mg: 0.55 mL 5 mM_5 mg: 2.74 mL 5 mM_10 mg: 5.48 mL

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.