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GCN1L1 Polyclonal Antibody, KO Validated, Unconjugated
| Product Name: |
GCN1L1 Polyclonal Antibody, KO Validated, Unconjugated |
| CAT#: |
DEERA-2402-LGZ-56 |
| Datasheet |
|
Description
Act as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Form a complex with EIF2AK4/GCN2 on translating ribosomes. During this process, GCN1 acts as a chaperone to facilitate the delivery of uncharged tRNAs entering the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, thereby stimulating its kinase activity. Participate in repressing global protein synthesis and activating gene-specific mRNA translation, such as ATF4 transcriptional activator, by promoting EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIFS21) at 'Ser-52'. This allows for ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion.
Basic Information
| Synonyms: |
GCN1, GCN1L1, GCN1L PRIC295 |
| Application: |
WB |
| Label/Conjugates: |
Unconjugated |
| Crossreactivity: |
Human |
| Source/Host: |
Rabbit |
| Uniprot: |
Q92616 |
| Buffer: |
50% glycerol, PBS with 0.01% thiomersal, pH7.3. |
| Concentration: |
1 mg/mL |
| Isotype: |
IgG |
| Purification: |
Affinity purification |
Immunogen Properties
| Calculated MW: |
292 kDa |
| Observed MW: |
293 kDa |
| Clonality: |
Polyclonal |
| Gene ID: |
10985 |
| Immunogen: |
Recombinant fusion protein derived from human GCN1L1 |
Shipping and Handling
| Stability & Storage: |
Store the sample at a temperature of -20°C and avoid subjecting it to repeated freeze/thaw cycles. |
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preclinical research use only and cannot be used to diagnose, treat or manage patients.
