GNE-781

Product Name:	GNE-781
CAT#:	DEHA-2312-LGZ-8
Package:	5mg/10mg/50mg/100mg
Datasheet

Description

GNE-781 is a highly potent and selective CBP inhibitor with an IC50 of 0.94 nM in TR-FRET experiments. The ic50s for inhibiting BRET and BRD4(1) are 6.2 nM and 5100 nM respectively.

Basic Information

Synonyms:	GNE 781; GNE781
Application:	CBP Inhibitor
CAS Number:	1936422-33-1
Formula:	C27H33F2N7O2
Molecular Weight:	525.59
SMILES:	O=C(N1CCC(N(C2CCOCC2)N=C3N4CCCC5=C4C=C(C(F)F)C(C6=CN(C)N=C6)=C5)=C3C1)NC
*Solubility-In vitro:*	DMSO: 96 mg/mL (182.65 mM) Water: Insoluble Ethanol: 96 mg/mL * <1 mg/ml means slightly soluble or insoluble.

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 19.03 mL 0.1 mM_5 mg: 95.13 mL 0.1 mM_10 mg: 190.26 mL 0.5 mM_1 mg: 3.81 mL 0.5 mM_5 mg: 19.03 mL 0.5 mM_10 mg: 38.05 mL 1 mM_1 mg: 1.9 mL 1 mM_5 mg: 9.51 mL 1 mM_10 mg: 19.03 mL 5 mM_1 mg: 0.38 mL 5 mM_5 mg: 1.9 mL 5 mM_10 mg: 3.81 mL

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