GSK J1

Product Name:	GSK J1
CAT#:	DEHD-2312-LGZ-5
Package:	10mg/25mg/50mg/100mg
Datasheet

Description

GSK J1 is a highly effective and selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX

Basic Information

Application:	Histone Demethylase Inhibitor
CAS Number:	1373422-53-7
Formula:	C22H23N5O2
Molecular Weight:	389.45
SMILES:	C1CN(CCC2=CC=CC=C21)C3=CC(=NC(=N3)C4=CC=CC=N4)NCCC(=O)O
*Solubility-In vitro:*	DMSO: 70 mg/mL (179.74 mM) Water: Insoluble Ethanol: Insoluble * <1 mg/ml means slightly soluble or insoluble.

Target Info

JMJD3 (KDM6B):	28 nM
UTX (KDM6A):	53 nM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 25.68 mL 0.1 mM_5 mg: 128.39 mL 0.1 mM_10 mg: 256.77 mL 0.5 mM_1 mg: 5.14 mL 0.5 mM_5 mg: 25.68 mL 0.5 mM_10 mg: 51.35 mL 1 mM_1 mg: 2.57 mL 1 mM_5 mg: 12.84 mL 1 mM_10 mg: 25.68 mL 5 mM_1 mg: 0.51 mL 5 mM_5 mg: 2.57 mL 5 mM_10 mg: 5.14 mL

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.