GSK126

Product Name:	GSK126
CAT#:	DEHM-2312-LGZ-3
Package:	2mg/5mg/10mg/25mg
Datasheet

Description

GSK126 is a highly effective, highly selective, S-adenosyl-methionine competitive small molecule inhibitor of EZH2 methyltransferase activity that reduces global H3K27me3 levels and reactivates silenced PRC2 target genes.

Basic Information

Synonyms:	GSK 126; GSK-126
Application:	EZH2 Inhibitor
CAS Number:	1346574-57-9
Formula:	C31H38N6O2
Molecular Weight:	526.67
SMILES:	CC[C@H](C)N1C=C(C2=C(C=C(C=C21)C3=CN=C(C=C3)N4CCNCC4)C(=O)NCC5=C(C=C(NC5=O)C)C)C
*Solubility-In vitro:*	In vitro (25°C): DMSO: Warmed: 3 mg/mL (5.69 mM) Water: Insoluble Ethanol: Insoluble
*Solubility-In vivo:*	4% DMSO+corn oil: 0.4 mg/mL

Target Info

EZH2:

9.9 nM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 18.99 mL 0.1 mM_5 mg: 94.94 mL 0.1 mM_10 mg: 189.87 mL 0.5 mM_1 mg: 3.8 mL 0.5 mM_5 mg: 18.99 mL 0.5 mM_10 mg: 37.97 mL 1 mM_1 mg: 1.9 mL 1 mM_5 mg: 9.49 mL 1 mM_10 mg: 18.99 mL 5 mM_1 mg: 0.38 mL 5 mM_5 mg: 1.9 mL 5 mM_10 mg: 3.8 mL

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.