GSK484 Hydrochloride

Product Name:	GSK484 Hydrochloride
CAT#:	DEPAD-2312-LGZ-2
Package:	5mg/10mg/50mg/100mg
Datasheet

Description

GSK484 hydrochloride, also known as GTPL8577, is a selective and reversible peptidylarginine deiminase 4 (PAD4) inhibitor.

Basic Information

Synonyms:	GSK 484,GSK-484; GTPL8577; GTPL-8577,GTPL 8577
Application:	PAD4 Inhibitor
CAS Number:	1652591-81-5
Formula:	C27H32ClN5O3
Molecular Weight:	510.03
SMILES:	O=C(N1C[C@H](N)[C@H](O)CC1)C2=CC(OC)=C3C(N=C(C(N4CC5CC5)=CC6=C4C=CC=C6)N3C)=C2.[H]Cl
*Solubility-In vitro:*	DMSO: 92 mg/mL (180.38 mM) Water: 7 mg/mL (13.72 mM) Ethanol: 92 mg/mL (180.38 mM) * <1 mg/ml means slightly soluble or insoluble.

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 19.61 mL 0.1 mM_5 mg: 98.03 mL 0.1 mM_10 mg: 196.07 mL 0.5 mM_1 mg: 3.92 mL 0.5 mM_5 mg: 19.61 mL 0.5 mM_10 mg: 39.21 mL 1 mM_1 mg: 1.96 mL 1 mM_5 mg: 9.8 mL 1 mM_10 mg: 19.61 mL 5 mM_1 mg: 0.39 mL 5 mM_5 mg: 1.96 mL 5 mM_10 mg: 3.92 mL

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