GSK591

Product Name:	GSK591
CAT#:	DEPAM-2312-LGZ-4
Package:	5mg/10mg/25mg
Datasheet

Description

GSK591 is a highly effective and selective inhibitor of the arginine methyltransferase PRMT5 with IC50 of 11 nM.

Basic Information

Synonyms:	EPZ015866,GSK3203591
Application:	PRMT5 Inhibitor
CAS Number:	1616391-87-7
Formula:	C22H28N4O2
Molecular Weight:	380.48
SMILES:	O=C(NC[C@H](O)CN1CCC(C=CC=C2)=C2C1)C3=CC(NC4CCC4)=NC=C3
*Solubility-In vitro:*	DMSO: 75 mg/mL (197.11 mM) Water: Insoluble Ethanol: 75 mg/mL (197.11 mM) * <1 mg/ml means slightly soluble or insoluble.

Target Info

PRMT5:

4nM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 26.28 mL 0.1 mM_5 mg: 131.41 mL 0.1 mM_10 mg: 262.83 mL 0.5 mM_1 mg: 5.26 mL 0.5 mM_5 mg: 26.28 mL 0.5 mM_10 mg: 52.57 mL 1 mM_1 mg: 2.63 mL 1 mM_5 mg: 13.14 mL 1 mM_10 mg: 26.28 mL 5 mM_1 mg: 0.53 mL 5 mM_5 mg: 2.63 mL 5 mM_10 mg: 5.26 mL

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.