INCB018424 (Ruxolitinib)

Product Name:	INCB018424 (Ruxolitinib)
CAT#:	DEJ-2312-LGZ-9
Package:	5mg/10mg/25mg/100mg/10mM * 1mL in DMSO
Datasheet

Description

INCB018424 is a highly effective and selective inhibitor of Janus-associated kinase (JAK) 1 and 2, with IC50 of JAK1, JAK2 and JAK3 are 2.7, 4.5 and 332 nM respectively.

Basic Information

Synonyms:	Ruxolitinib; INCB18424
Application:	JAK1/2 Inhibitor
CAS Number:	941678-49-5
Formula:	C17H18N6
Molecular Weight:	306.4
SMILES:	C1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
*Solubility-In vitro:*	In vitro (25°C): DMSO: 59 mg/mL (192.57 mM) Water: Insoluble Ethanol: 59 mg/mL (192.57 mM)
*Solubility-In vivo:*	2% DMSO+30% PEG 300+ddH2O: 4 mg/mL

Target Info

JAK2:	2.8 nM (IC50)
JAK1:	3.3 nM (IC50)
Tyk2:	19 nM (IC50)
JAK3:	428 nM (IC50)

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 32.64 mL 0.1 mM_5 mg: 163.19 mL 0.1 mM_10 mg: 326.37 mL 0.5 mM_1 mg: 6.53 mL 0.5 mM_5 mg: 32.64 mL 0.5 mM_10 mg: 65.27 mL 1 mM_1 mg: 3.26 mL 1 mM_5 mg: 16.32 mL 1 mM_10 mg: 32.64 mL 5 mM_1 mg: 0.65 mL 5 mM_5 mg: 3.26 mL 5 mM_10 mg: 6.53 mL

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