IOX1

Product Name:	IOX1
CAT#:	DEHD-2312-LGZ-10
Package:	10mg/25mg/50mg
Datasheet

Description

IOX1 is a highly effective and broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases.

Basic Information

Synonyms:	IOX 1; Iox-1
Application:	2OG Oxygenases Inhibitor
CAS Number:	5852-78-8
Formula:	C10H7NO3
Molecular Weight:	189.17
SMILES:	C1=CC2=C(C=CC(=C2N=C1)O)C(=O)O
*Solubility-In vitro:*	DMSO: 36 mg/mL (190.3 mM) Water: Insoluble Ethanol: Insoluble * <1 mg/ml means slightly soluble or insoluble.

Target Info

KDM3A: IC50:	0.1μM
KDM4C: IC50:	0.6μM
KDM6B: IC50:	1.6μM
KDM2A: IC50:	1.8μM
KDM4E: IC50:	2.3μM
KDM5C: IC50:	19μM
PHD2: IC50:	33μM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 52.86 mL 0.1 mM_5 mg: 264.31 mL 0.1 mM_10 mg: 528.63 mL 0.5 mM_1 mg: 10.57 mL 0.5 mM_5 mg: 52.86 mL 0.5 mM_10 mg: 105.73 mL 1 mM_1 mg: 5.29 mL 1 mM_5 mg: 26.43 mL 1 mM_10 mg: 52.86 mL 5 mM_1 mg: 1.06 mL 5 mM_5 mg: 5.29 mL 5 mM_10 mg: 10.57 mL

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