ITF2357 (Givinostat)

Product Name:	ITF2357 (Givinostat)
CAT#:	DEH-2312-LGZ-3
Package:	5mg/10mg/50mg/100mg/10mM * 1mL in DMSO
Datasheet

Description

ITF2357, also known as Givinostat, is an HDACs inhibitor with potential anti-inflammatory, anti-angiogenic and anti-tumor activities.

Basic Information

Synonyms:	Gavinostat
Application:	HDAC Inhibitor
CAS Number:	732302-99-7
Formula:	C24H27N3O4.HCl.H2O
Molecular Weight:	476
SMILES:	CC[NH+](CC)CC1=CC2=C(C=C1)C=C(C=C2)COC(=O)NC3=CC=C(C=C3)C(=O)NO.O.[Cl-]
*Solubility-In vitro:*	In vitro (25°C): DMSO: 94 mg/mL (197.49 mM) Water: Insoluble Ethanol: 3 mg/mL
*Solubility-In vivo:*	5%DMSO+40%PEG300++5%Tween80+50%ddH2O: 4 mg/mL

Target Info

HD1-B (Cell-free assay):	7.5 nM
HD2 (Cell-free assay):	10 nM
HD1-A (Cell-free assay):	16 nM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 21.01 mL 0.1 mM_5 mg: 105.04 mL 0.1 mM_10 mg: 210.08 mL 0.5 mM_1 mg: 4.2 mL 0.5 mM_5 mg: 21.01 mL 0.5 mM_10 mg: 42.02 mL 1 mM_1 mg: 2.1 mL 1 mM_5 mg: 10.5 mL 1 mM_10 mg: 21.01 mL 5 mM_1 mg: 0.42 mL 5 mM_5 mg: 2.1 mL 5 mM_10 mg: 4.2 mL

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