JIB-04

Product Name:	JIB-04
CAT#:	DEHD-2312-LGZ-9
Package:	25mg/50mg/100mg/10mM * 1mL in DMSO
Datasheet

Description

JIB-04 is a pan-selective Jumonji histone demethylase inhibitor, its IC50 values are 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively.

Basic Information

Synonyms:	NSC 693627; JIB04
Application:	Histone Demethylase Inhibitor
CAS Number:	199596-05-9
Formula:	C17H13ClN4
Molecular Weight:	308.76
SMILES:	C1=CC=C(C=C1)/C(=N\NC2=NC=C(C=C2)Cl)/C3=CC=CC=N3
*Solubility-In vitro:*	In vitro (25°C): DMSO: Warmed: 22 mg/mL (71.24 mM) Water: Insoluble Ethanol: Insoluble
*Solubility-In vivo:*	4% DMSO+corn oil: 2 mg/mL

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 32.39 mL 0.1 mM_5 mg: 161.94 mL 0.1 mM_10 mg: 323.88 mL 0.5 mM_1 mg: 6.48 mL 0.5 mM_5 mg: 32.39 mL 0.5 mM_10 mg: 64.78 mL 1 mM_1 mg: 3.24 mL 1 mM_5 mg: 16.19 mL 1 mM_10 mg: 32.39 mL 5 mM_1 mg: 0.65 mL 5 mM_5 mg: 3.24 mL 5 mM_10 mg: 6.48 mL

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