KPT 335

Product Name:	KPT 335
CAT#:	DMC-2312-LGZ-4
Package:	5mg/10mg/50mg
Datasheet

Description

KPT 335 is an orally bioavailable selective Nuclear Export (SINE) inhibitor.

Basic Information

Synonyms:	Verdinexor
Application:	SINE Inhibitor
CAS Number:	1392136-43-4
Formula:	C18H12F6N6O
Molecular Weight:	442.32
SMILES:	O=C(NNC1=NC=CC=C1)/C=C\N2N=C(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)N=C2
*Solubility-In vitro:*	In vitro (25°C): DMSO: 83 mg/mL (187.65 mM) Water: Insoluble Ethanol: Warmed: 10 mg/mL
*Solubility-In vivo:*	5% DMSO+corn oil: 14 mg/mL

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 22.61 mL 0.1 mM_5 mg: 113.04 mL 0.1 mM_10 mg: 226.08 mL 0.5 mM_1 mg: 4.52 mL 0.5 mM_5 mg: 22.61 mL 0.5 mM_10 mg: 45.22 mL 1 mM_1 mg: 2.26 mL 1 mM_5 mg: 11.3 mL 1 mM_10 mg: 22.61 mL 5 mM_1 mg: 0.45 mL 5 mM_5 mg: 2.26 mL 5 mM_10 mg: 4.52 mL

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