KPT276

Product Name:	KPT276
CAT#:	DMC-2312-LGZ-5
Package:	10mg/25mg/50mg
Datasheet

Description

KPT276, analog of KPT-185, is a selective nuclear export (SINE) and CRM1 inhibitor.

Basic Information

Synonyms:	KPT-276; KPT 276
Application:	SINE/CRM1 Inhibitor
CAS Number:	1421919-75-6
Formula:	C16H10F8N4O
Molecular Weight:	426.26
SMILES:	C1C(CN1C(=O)C=CN2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)(F)F
*Solubility-In vitro:*	In vitro (25°C): DMSO: 17 mg/mL (39.87 mM) Water: Insoluble Ethanol: Insoluble
*Solubility-In vivo:*	30% PEG400+0.5% Tween80+5% propylene glycol: 4 mg/mL

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 23.46 mL 0.1 mM_5 mg: 117.3 mL 0.1 mM_10 mg: 234.6 mL 0.5 mM_1 mg: 4.69 mL 0.5 mM_5 mg: 23.46 mL 0.5 mM_10 mg: 46.92 mL 1 mM_1 mg: 2.35 mL 1 mM_5 mg: 11.73 mL 1 mM_10 mg: 23.46 mL 5 mM_1 mg: 0.47 mL 5 mM_5 mg: 2.35 mL 5 mM_10 mg: 4.69 mL

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