LAQ824 (NVP-LAQ824, Dacinostat)

Product Name:	LAQ824 (NVP-LAQ824, Dacinostat)
CAT#:	DEH-2312-LGZ-5
Package:	10mg/50mg/100mg/(NVP-LAQ824) 10mM * 1mL in DMSO
Datasheet

Description

LAQ824 (NVP-LAQ824) is a highly effective novel histone deacetylase inhibitor with significant therapeutic activity against multiple myeloma.

Basic Information

Synonyms:	NVP-LAQ824; Dacinostat; LAQ-824
Application:	HDAC Inhibitor
CAS Number:	404951-53-7
Formula:	C22H25N3O3
Molecular Weight:	379.5
SMILES:	C1=CC=C2C(=C1)C(=CN2)CCN(CCO)CC3=CC=C(C=C3)/C=C/C(=O)NO
*Solubility-In vitro:*	In vitro (25°C): DMSO: 66 mg/mL (173.93 mM) Water: Insoluble Ethanol: Insoluble
*Solubility-In vivo:*	5%DMSO+40%PEG300+5%Tween80+50%ddH2O: 14 mg/mL

Target Info

HDAC:

32 nM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 26.35 mL 0.1 mM_5 mg: 131.75 mL 0.1 mM_10 mg: 263.5 mL 0.5 mM_1 mg: 5.27 mL 0.5 mM_5 mg: 26.35 mL 0.5 mM_10 mg: 52.7 mL 1 mM_1 mg: 2.64 mL 1 mM_5 mg: 13.18 mL 1 mM_10 mg: 26.35 mL 5 mM_1 mg: 0.53 mL 5 mM_5 mg: 2.64 mL 5 mM_10 mg: 5.27 mL

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