LBH589 (Panobinostat)

Product Name:	LBH589 (Panobinostat)
CAT#:	DEH-2312-LGZ-6
Package:	10mg/50mg/100mg/200mg/(Panobinostat) 10mM * 1mL in DMSO
Datasheet

Description

LBH589 is a hydroxamic acid and a non-selective HDAC inhibitor with an IC5o of 0.23 nM for HDAC1.

Basic Information

Synonyms:	NVP-LBH589; LBH-589
Application:	HDAC Inhibitor
CAS Number:	404950-80-7
Formula:	C21H23N3O2
Molecular Weight:	349.4
SMILES:	CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO
*Solubility-In vitro:*	In vitro (25°C): DMSO: 60 mg/mL (171.7 mM) Water: Insoluble Ethanol: Insoluble
*Solubility-In vivo:*	2% DMSO+48% PEG 300+2% Tween 80+ddH2O: 4 mg/mL

Target Info

HDAC (MOLT-4 cells):	5 nM
HDAC (Reh cells):	20 nM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 28.62 mL 0.1 mM_5 mg: 143.1 mL 0.1 mM_10 mg: 286.2 mL 0.5 mM_1 mg: 5.72 mL 0.5 mM_5 mg: 28.62 mL 0.5 mM_10 mg: 57.24 mL 1 mM_1 mg: 2.86 mL 1 mM_5 mg: 14.31 mL 1 mM_10 mg: 28.62 mL 5 mM_1 mg: 0.57 mL 5 mM_5 mg: 2.86 mL 5 mM_10 mg: 5.72 mL

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