Leptomycin B

Product Name:	Leptomycin B
CAT#:	DMC-2312-LGZ-7
Package:	1mg/5mg/10mg
Datasheet

Description

Leptomycin B is a highly effective protein nuclear export inhibitor that inactivates CRM1/exportin 1 by covalently modifying cysteine residues. It is also a highly effective antifungal antibiotic that blocks the eukaryotic cell cycle.

Basic Information

Synonyms:	CI 940; CI940; CI-940; LMB
Application:	Nuclear Export Receptor CRM1 Inhibitor
CAS Number:	87081-35-4
Formula:	C33H48O6
Molecular Weight:	540.73
SMILES:	O=C(O)/C=C(C)/C[C@H](C)[C@@H](O)[C@H](C)C([C@H](C)/C=C(C)/C=C/C[C@@H](C)/C=C(CC)\C=C\[C@H]1[C@@H](C)C=CC(O1)=O)=O

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

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