LY2784544 (Gandotinib)

Product Name:	LY2784544 (Gandotinib)
CAT#:	DEJ-2312-LGZ-8
Package:	5mg/10mg/25mg/100mg/10mM * 1mL in DMSO
Datasheet

Description

LY2784544 is highly selective for JAK2-V617F and has entered human clinical trials for the treatment of several myeloproliferative diseases.

Basic Information

Application:	JAK Inhibitor
CAS Number:	1229236-86-5
Formula:	C23H25ClFN7O
Molecular Weight:	469.9
SMILES:	CC1=CC(=NN1)NC2=NN3C(=C(N=C3C(=C2)CN4CCOCC4)C)CC5=C(C=C(C=C5)Cl)F
*Solubility-In vitro:*	DMSO: 92 mg/mL (195.76 mM) Water: Insoluble Ethanol: 9 mg/mL (19.15 mM) * <1 mg/ml means slightly soluble or insoluble.

Target Info

JAK2(V617F): ki:	0.245nM
JAK2: ki:	0.288nM
JAK2: IC50:	2.52nM
FLT3: IC50:	4nM
JAK1: IC50:	19.8nM
FLT4: IC50:	25nM
FGFR2: IC50:	32nM
TYK2: IC50:	44nM
JAK3: IC50:	48.0nM
TrkB: IC50:	95nM
FGFR3: IC50:	106nM
KDR: IC50:	109nM
ALK: IC50:	138nM
MUSK: IC50:	147nM
AuroraA: IC50:	168nM
MAP3K9: IC50:	299nM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 21.28 mL 0.1 mM_5 mg: 106.41 mL 0.1 mM_10 mg: 212.81 mL 0.5 mM_1 mg: 4.26 mL 0.5 mM_5 mg: 21.28 mL 0.5 mM_10 mg: 42.56 mL 1 mM_1 mg: 2.13 mL 1 mM_5 mg: 10.64 mL 1 mM_10 mg: 21.28 mL 5 mM_1 mg: 0.43 mL 5 mM_5 mg: 2.13 mL 5 mM_10 mg: 4.26 mL

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.