MGCD0103 (Mocetinostat)

Product Name:	MGCD0103 (Mocetinostat)
CAT#:	DEH-2312-LGZ-8
Package:	5mg/10mg/25mg/50mg/(Mocetinostat) 10mM * 1mL in DMSO
Datasheet

Description

MGCD0103 (Mocetinostat) is a benzamide histone deacetylase inhibitor that primarily inhibits histone deacetylase 1 (HDAC1) and also inhibits HDAC2, HDAC3 and HDAC11.

Basic Information

Synonyms:	MGCD-0103
Application:	HDAC Inhibitor
CAS Number:	726169-73-9
Formula:	C23H20N6O
Molecular Weight:	396.4
SMILES:	C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC3=NC=CC(=N3)C4=CN=CC=C4
*Solubility-In vitro:*	In vitro (25°C): DMSO: 12 mg/mL (30.27 mM) Water: Insoluble Ethanol: Insoluble
*Solubility-In vivo:*	30% PEG400+0.5% Tween80+5% Propylene glycol: 28 mg/mL

Target Info

HDAC1: IC50:	0.15μM
HDAC2: IC50:	0.29μM
HDAC11: IC50:	0.59μM
HDAC3: IC50:	1.66μM
HDAC4: IC50:	>10μM
HDAC5: IC50:	>10μM
HDAC6: IC50:	>10μM
HDAC7: IC50:	>10μM
HDAC8: IC50:	>10μM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 25.23 mL 0.1 mM_5 mg: 126.14 mL 0.1 mM_10 mg: 252.27 mL 0.5 mM_1 mg: 5.05 mL 0.5 mM_5 mg: 25.23 mL 0.5 mM_10 mg: 50.45 mL 1 mM_1 mg: 2.52 mL 1 mM_5 mg: 12.61 mL 1 mM_10 mg: 25.23 mL 5 mM_1 mg: 0.5 mL 5 mM_5 mg: 2.52 mL 5 mM_10 mg: 5.05 mL

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