MK-4827 (Niraparib)

Product Name:	MK-4827 (Niraparib)
CAT#:	DEPA-2312-LGZ-8
Package:	5mg/10mg
Datasheet

Description

MK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor.

Basic Information

Synonyms:	MK4827
Application:	PARP Inhibitor
CAS Number:	1038915-60-4
Formula:	C19H20N4O
Molecular Weight:	320.4
SMILES:	C1C[C@H](CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N
*Solubility-In vitro:*	In vitro (25°C): DMSO: 60 mg/mL (187.27 mM) Water: Insoluble Ethanol: 60 mg/mL (187.27 mM)
*Solubility-In vivo:*	10% DMSO+40% PEG 300+5% Tween 80+ddH2O: 9 mg/mL

Target Info

PARP-2:	2.1 nM (IC50)
PARP-1:	3.8 nM (IC50)
V-PARP:	330 nM (IC50)
TANK-1:	570 nM (IC50)
PARP-3:	1300 nM (IC50)

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 31.21 mL 0.1 mM_5 mg: 156.05 mL 0.1 mM_10 mg: 312.11 mL 0.5 mM_1 mg: 6.24 mL 0.5 mM_5 mg: 31.21 mL 0.5 mM_10 mg: 62.42 mL 1 mM_1 mg: 3.12 mL 1 mM_5 mg: 15.61 mL 1 mM_10 mg: 31.21 mL 5 mM_1 mg: 0.62 mL 5 mM_5 mg: 3.12 mL 5 mM_10 mg: 6.24 mL

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