MS-275 (Entinostat)

Product Name:	MS-275 (Entinostat)
CAT#:	DEH-2312-LGZ-9
Package:	10mg/25mg/50mg/200mg/(Entinostat) 10mM * 1mL in DMSO
Datasheet

Description

MS-275, also called Entinostat, is a highly effective HDAC inhibitor with IC50s of 0.3 and 8uM for HDAC1 and HDAC3 respectively.

Basic Information

Synonyms:	SNDX-275
Application:	HDAC Inhibitor
CAS Number:	209783-80-2
Formula:	C21H20N4O3
Molecular Weight:	376.4
SMILES:	C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3
*Solubility-In vitro:*	In vitro (25°C): DMSO: 71 mg/mL (188.62 mM) Water: Insoluble Ethanol: Insoluble
*Solubility-In vivo:*	2% DMSO+30% PEG 300+ddH2O: 9 mg/mL

Target Info

HDAC1 (Cell-free assay):	0.51 μM
HDAC3 (Cell-free assay):	1.7 μM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 26.57 mL 0.1 mM_5 mg: 132.84 mL 0.1 mM_10 mg: 265.67 mL 0.5 mM_1 mg: 5.31 mL 0.5 mM_5 mg: 26.57 mL 0.5 mM_10 mg: 53.13 mL 1 mM_1 mg: 2.66 mL 1 mM_5 mg: 13.28 mL 1 mM_10 mg: 26.57 mL 5 mM_1 mg: 0.53 mL 5 mM_5 mg: 2.66 mL 5 mM_10 mg: 5.31 mL

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