NSC87877

Product Name:	NSC87877
CAT#:	DEPTP-2312-LGZ-6
Package:	10mg/25mg/100mg
Datasheet

Description

NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 (IC50 values are 355 and 318 nM respectively).

Basic Information

Synonyms:	NSC-87877; NSC 87877
Application:	SHP Inhibitor
CAS Number:	56932-43-5
Formula:	C19H13N3O7S2.2Na
Molecular Weight:	503.42
SMILES:	C1=CC2=C(C(=O)C(=NNC3=CC4=C(C=C3)C=C(C=C4)S(=O)(=O)[O-])C=C2S(=O)(=O)[O-])N=C1.[Na+].[Na+]
*Solubility-In vitro:*	In vitro (25°C): DMSO: 85 mg/mL (168.84 mM) Water: 85 mg/mL (168.84 mM) Ethanol: Insoluble
*Solubility-In vivo:*	2% DMSO+35% PEG 300+2% Tween 80+ddH2O: 5 mg/mL

Target Info

SHP-2:	318 nM
SHP-1:	355 nM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 19.86 mL 0.1 mM_5 mg: 99.32 mL 0.1 mM_10 mg: 198.64 mL 0.5 mM_1 mg: 3.97 mL 0.5 mM_5 mg: 19.86 mL 0.5 mM_10 mg: 39.73 mL 1 mM_1 mg: 1.99 mL 1 mM_5 mg: 9.93 mL 1 mM_10 mg: 19.86 mL 5 mM_1 mg: 0.4 mL 5 mM_5 mg: 1.99 mL 5 mM_10 mg: 3.97 mL

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