NVP-BSK805

Product Name:	NVP-BSK805
CAT#:	DEJ-2312-LGZ-10
Package:	5mg/10mg/50mg/100mg/10mM * 1mL in DMSO
Datasheet

Description

NVP-BSK805 is an inhibition of polycythemia by the quinoxaline JAK2 inhibitor that potently suppressed recombinant human erythropoietin-induced polycythemia and extramedullary erythropoiesis in mice and rats.

Basic Information

Synonyms:	NVPBSK805
Application:	JAK Inhibitor
CAS Number:	1092499-93-8
Formula:	C27H28F2N6O.2HCl
Molecular Weight:	563.47
SMILES:	C1CNCCC1N2C=C(C=N2)C3=NC4=C(C=CC=C4N=C3)C5=CC(=C(C(=C5)F)CN6CCOCC6)F.Cl.Cl

Target Info

JAK2 JH1:	0.48 nM (IC50)
JAK2(V617F):	0.56 nM (IC50)
FL JAK2 wt:	0.58 nM (IC50)
TYK2 JH1:	18.68 nM (IC50)
JAK1 JH1:	31.68 nM (IC50)

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.