Olaparib (AZD2281)

Product Name:	Olaparib (AZD2281)
CAT#:	DEPA-2312-LGZ-5
Package:	10mg/25mg/50mg/100mg/(AZD2281) 10mM * 1mL in DMSO
Datasheet

Description

Olaparib (AZD2281) is an enzyme involved in DNA repair.

Basic Information

Synonyms:	KU-0059436
Application:	PARP Inhibitor
CAS Number:	763113-22-0
Formula:	C24H23FN4O3
Molecular Weight:	434.5
SMILES:	C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F
*Solubility-In vitro:*	In vitro (25°C): DMSO: Warmed: 74 mg/mL (170.32 mM) Water: Ethanol: Insoluble
*Solubility-In vivo:*	4% DMSO+30% PEG 300+ddH2O: 4 mg/mL

Target Info

PARP2 (Cell-free assay):	1 nM
PARP1 (Cell-free assay):	5 nM
Tankyrase-1 (Cell-free assay):	1.5 μM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 23.01 mL 0.1 mM_5 mg: 115.07 mL 0.1 mM_10 mg: 230.15 mL 0.5 mM_1 mg: 4.6 mL 0.5 mM_5 mg: 23.01 mL 0.5 mM_10 mg: 46.03 mL 1 mM_1 mg: 2.3 mL 1 mM_5 mg: 11.51 mL 1 mM_10 mg: 23.01 mL 5 mM_1 mg: 0.46 mL 5 mM_5 mg: 2.3 mL 5 mM_10 mg: 4.6 mL

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