PCI-24781 (Abexinostat)

Product Name:	PCI-24781 (Abexinostat)
CAT#:	DEH-2312-LGZ-10
Package:	5mg/10mg/50mg/100mg/10mM * 1mL in DMSO
Datasheet

Description

PCI-24781 is a broad-spectrum phenyl hydroxamic acid HDAC inhibitor.

Basic Information

Synonyms:	PCI24781; CRA-024781
Application:	HDAC Inhibitor
CAS Number:	783355-60-2
Formula:	C21H23N3O5
Molecular Weight:	397.4
SMILES:	CN(C)CC1=C(OC2=CC=CC=C21)C(=O)NCCOC3=CC=C(C=C3)C(=O)NO
*Solubility-In vitro:*	DMSO: 72 mg/mL (181.16 mM) Water: Insoluble Ethanol: Insoluble * <1 mg/ml means slightly soluble or insoluble.

Target Info

HDAC1: ki:	7nM
HDAC3/SMRT: ki:	8.2nM
HDAC6: ki:	17nM
HDAC2: ki:	19nM
HDAC10: IC50:	24nM
HDAC8: IC50:	280nM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 25.16 mL 0.1 mM_5 mg: 125.82 mL 0.1 mM_10 mg: 251.64 mL 0.5 mM_1 mg: 5.03 mL 0.5 mM_5 mg: 25.16 mL 0.5 mM_10 mg: 50.33 mL 1 mM_1 mg: 2.52 mL 1 mM_5 mg: 12.58 mL 1 mM_10 mg: 25.16 mL 5 mM_1 mg: 0.5 mL 5 mM_5 mg: 2.52 mL 5 mM_10 mg: 5.03 mL

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