Piperlongumine

Product Name:	Piperlongumine
CAT#:	DMC-2312-LGZ-3
Package:	25mg/50mg/10mM * 1mL in DMSO
Datasheet

Description

Piperlongumine exhibits selective cytotoxicity towards cancer cells, independent of their p53 status, while sparing normal cells. Its mechanism of action involves binding to and inhibiting proteins involved in the regulation of oxidative stress, notably Glutathione S-transferase pi 1 (GSTP1).

Basic Information

Synonyms:	Piplartine
Application:	TrxR1/CRM1 Inhibitor
CAS Number:	20069-09-4
Formula:	C17H19NO5
Molecular Weight:	317.3
SMILES:	COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCC=CC2=O
*Solubility-In vitro:*	In vitro (25°C): DMSO: Warmed: 15 mg/mL (47.26 mM) Water: Insoluble Ethanol: Warmed: 6 mg/mL (18.9 mM)
*Solubility-In vivo:*	2% DMSO+40% PEG 300+2% Tween 80+ddH2O: 4 mg/mL

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 31.52 mL 0.1 mM_5 mg: 157.58 mL 0.1 mM_10 mg: 315.16 mL 0.5 mM_1 mg: 6.3 mL 0.5 mM_5 mg: 31.52 mL 0.5 mM_10 mg: 63.03 mL 1 mM_1 mg: 3.15 mL 1 mM_5 mg: 15.76 mL 1 mM_10 mg: 31.52 mL 5 mM_1 mg: 0.63 mL 5 mM_5 mg: 3.15 mL 5 mM_10 mg: 6.3 mL

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