(±)-Propranolol Hydrochloride
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Description
(±)-Propranolol hydrochloride is a β-adrenergic receptor (β-AR) antagonist (Kds for human β1, β2, and β3-AR are 6.91, 0.832, and 117.49 nM, respectively). It also acts as a non-specific 5-HT1/5-HT2 serotonin receptor antagonist, reducing transaminocypromine/L-tryptophan-induced hyperactivity in rats. (±)-Propranolol hydrochloride is an effective antihypertensive, cardiodepressant, and also used to treat angina pectoris. It reduces the effects of stress and exercise on the heart by reducing contraction rate and impulse conduction. Known to competitively block the effects of catecholamines.
Basic Information
| CAS Number: | 318-98-9 |
| Formula: | C16H21NO2. HCl |
| Molecular Weight: | 295.8 |
| Synonyms: | (±)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride; DL-Propranolol hydrochloride; ICI 45520; NSC 91523 |
| InChi Key: | ZMRUPTIKESYGQW-UHFFFAOYSA-N |
| Appearance: | White powder |
| Purity Chemicals: | ≥99% (TLC) |
| SMILES: | OC(CNC(C)C)COC1=CC=CC2=CC=CC=C21.Cl |
| Solubility: | Soluble in DMSO (15 mg/ml), ethanol (10 mg/ml) or water (20 mg/ml). Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution. |
Shipping and Handling
| Storage (Short Term): | 20°C |
| Storage (Long Term): | 4°C |
| Shipping: | Ambient |
| Handling Advice: | Keep under inert gas. Very hygroscopic. |
| Stability: | When stored at a temperature of +4°C, it remains stable for at least 2 years. |
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