PROseq Human Exome Kit

This kit contains probes, blocking oligos, and reagents for hybrid capture and post-hybrid capture amplification for whole exome enrichment. It's designed to process up to 24/96 Illumina-compatible libraries in pools of 8, accommodating 3/12 hybridization capture reactions.

Features

Quickly set up a scalable and automated workflow, with data analysis and variant interpretation solutions pre-set, in a single day.
With a fast analysis and interpretation of data, you can efficiently and easily identify disease-related variants, eliminating data blockage and decreasing the overall waiting period.

Product Details

PROseq Human Exome Kits significantly enhance read utilization and cut sequencing costs by up to 50%, offering top-quality SNV, Indel and CNV calls. They offer 99% base-level coverage with ≥20x depth, allowing >98% collective sensitivity for SNVs and Indels while decreasing dropouts. The one-day, automation-friendly sample to sequencing procedure is more than 33% swifter compared to other exome workflows. It facilitates outstanding coverage uniformity with changeable hybridization times, requiring as little as 30 minutes, even for FFPE and cfDNA samples. Also, PROseq Human Exome workflow eradicates the data bottleneck and lessens the total turnaround time with swift data analysis and variant interpretation. It enables a quick transition from FASTQ files to top-quality variant calls in 60 minutes with the PROTHERAGEN CLC Genomics Workbench, which is 57% quicker than the traditional BWA - GATK pipelines. This, coupled with reducing up to 80% of the time and complexity involved in large-scale interpretation, provides superior quality variant- and disease-specific evidence for interpretation using PROTHERAGEN Clinical Insight (QCI) for PROseq.

Applications

The extensive use of exome sequencing has paved the way for various, economical methods for disease-oriented research. Various applications that employ exome sequencing can use PROseq Human Exome Kits, including:
Identifying disease genes for uncommon and familial diseases
Studying population genetics and carrier screening
Researching human disease pathways and mechanisms
Investigating pathogenic infection mechanisms.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.