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PROseq Targeted DNA Pro Custom

First of the four necessary sets for multiplexing up to 384 samples, the box contains unique dual-indexed primers for indexing as many as 96 samples for PROseq Targeted DNA Pro Panel sequencing on Illumina platforms.

Features

The total turnaround time to transition from setup to sequencing is less than six hours. The ability to multiplex PROseq Targeted DNA Pro Custom libraries with other chemistries should be offered for added flexibility. A new enzymatic process is in place to prevent adapter and primer carryover contamination, eliminating the need for time-consuming bead purifications. In addition to SNPs and indels, structural variants with breakpoints are revealed, which are defined at the nucleotide level and span multiple exons.

Product Details

The PROseq Targeted DNA Pro Custom Panels redefine the standard for NGS genotyping. This new chemistry holds significant advancements that enhance ease-of-use, efficiency, and comprehensive variant analysis. This specially developed DNA target enrichment technique presents a solution that is conducive to automation, simultaneously enabling exceptionally sensitive variant detection through integrated unique molecular indices (UMIs). The tool is primed for detecting various genetic variations such as somatic mutations, single nucleotide polymorphisms, copy number variation, and small insertions/deletions. We offer customization options beyond our established panels. The kits have been fine-tuned for use with our PROseq Targeted Pro Panel Unique Dual-Index primers compatible with Illumina sequencing systems, and Ion-compatible adapters suited for sequencing on Ion platforms.

Applications

A diverse array of DNA variants can be detected from numerous types of samples using the PROseq Targeted DNA Pro Custom Panels. There are a multitude of applications for these panels. The various DNA variants that can be identified include SNVs, small indels, CNVs, select structural variants with well-known breakpoints, and loss of heterozygosity (LOH). They can be employed on a variety of sample types such as FFPE, plasma/serum, fresh or frozen tissue, and cell lines. As for applications, these panels can be utilized for tasks such as profiling DNA variants in solid tumor and hematologic malignancies, hotspot detection in solid tumors, and examining variants in mitochondrial DNA.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.