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PROseq xHYB Carrier Panel 

The PROseq xHYB panels include materials needed for the hybridization of specifically targeted probes that enable enrichment of curated genomic regions from DNA libraries prepared for NGS, like those produced using PROseq FX Library Kits (available separately). The package comprises materials sufficient for carrier testing of up to 24 samples.

Features

HGMD-curated panels are available for covering entire genes and coding sequences of proteins (CDS). Process workflow for a single day provides flexibility with hybrid capture ranging anywhere between 30 minutes and overnight. There has been a decrease in the fold-80 base penalty, which allows for maximized on-target coverage and reduces the cost of sequencing. Rapid data analysis and variant interpretation can eliminate data bottlenecks and reduce the overall time required.

Product Details

The PROseq xHYB Portfolio is a collection of extensive panels targeting genomic regions with relevant known genomic variants. They are built using variant data from the Human Gene Mutation Database (HGMD) and provide extensive coverage of genes. The design of these panels optimizes probe coverage, including the most challenging genomic regions. This entire collection allows for maximum read utilization, reducing sequencing costs by up to 50%. It provides high-quality SNV, indel and CNV calls, and maintains 99% base-level coverage at ≥20x depth. The process is efficient, with a sample-to-sequencing workflow that is faster than other exome workflows. This process provides excellent coverage uniformity across variable hybridization times, whether using FFPE or cfDNA samples.

Applications

The extensive use of exome sequencing has paved the way for various, economical methods for disease-oriented research. Various applications that employ exome sequencing can use PROseq Human Exome Kits, including: Identifying disease genes for uncommon and familial diseases Studying population genetics and carrier screening Researching human disease pathways and mechanisms Investigating pathogenic infection mechanisms.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.