RMC-4550

Product Name:	RMC-4550
CAT#:	DEPTP-2312-LGZ-10
Package:	1mg/5mg/10mg/50mg
Datasheet

Description

RMC-4550 is a highly potent, selective and allosteric inhibitor of SHP2 (IC50 = 0.583 nM).

Basic Information

Synonyms:	RMC4550; RMC-4550
Application:	SHP2 Inhibitor
CAS Number:	2172651-73-7
Formula:	C21H26Cl2N4O2
Molecular Weight:	437.36
SMILES:	ClC1=C(Cl)C(C2=NC(CO)=C(N3CCC4(CO[C@@H](C)[C@H]4N)CC3)N=C2C)=CC=C1
*Solubility-In vitro:*	DMSO: 91 mg/mL (208.06 mM) * <1 mg/ml means slightly soluble or insoluble.

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 22.86 mL 0.1 mM_5 mg: 114.32 mL 0.1 mM_10 mg: 228.64 mL 0.5 mM_1 mg: 4.57 mL 0.5 mM_5 mg: 22.86 mL 0.5 mM_10 mg: 45.73 mL 1 mM_1 mg: 2.29 mL 1 mM_5 mg: 11.43 mL 1 mM_10 mg: 22.86 mL 5 mM_1 mg: 0.46 mL 5 mM_5 mg: 2.29 mL 5 mM_10 mg: 4.57 mL

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.