Selinexor (KPT-330)

Product Name:	Selinexor (KPT-330)
CAT#:	DMC-2312-LGZ-1
Package:	5mg/10mg/25mg/50mg/KPT-330 10mM * 1mL in DMSO
Datasheet

Description

KPT-330 inhibitor of CRM1 (XPO1) mediates nuclear export with selective antileukemic activity in preclinical models of acute T lymphoblastic leukemia and acute myeloid leukemia.

Basic Information

Synonyms:	KPT330; KPT 330
Application:	CRM1 Inhibitor
CAS Number:	1393477-72-9
Formula:	C17H11F6N7O
Molecular Weight:	443.31
SMILES:	C1=CN=C(C=N1)NNC(=O)/C=C\N2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
*Solubility-In vitro:*	In vitro (25°C): DMSO: 78 mg/mL (175.94 mM) Water: Insoluble Ethanol: 36 mg/mL (81.21 mM)
*Solubility-In vivo:*	2% DMSO+40%PEG 300+5% Tween80 +ddH2O: 3 mg/mL

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 22.56 mL 0.1 mM_5 mg: 112.79 mL 0.1 mM_10 mg: 225.58 mL 0.5 mM_1 mg: 4.51 mL 0.5 mM_5 mg: 22.56 mL 0.5 mM_10 mg: 45.12 mL 1 mM_1 mg: 2.26 mL 1 mM_5 mg: 11.28 mL 1 mM_10 mg: 22.56 mL 5 mM_1 mg: 0.45 mL 5 mM_5 mg: 2.26 mL 5 mM_10 mg: 4.51 mL

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.