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SGC 707
Description
SGC 707 is a highly effective PRMT3 allosteric inhibitor (IC50 = 50 nM) with over 100-fold selectivity over other methyltransferases and other non-epigenetic targets.
Basic Information
Synonyms: | SGC707; SGC-707 |
Application: | PRMT3 Inhibitor |
CAS Number: | 1687736-54-4 |
Formula: | C16H18N4O2 |
Molecular Weight: | 298.3 |
SMILES: | C1CCN(C1)C(=O)CNC(=O)NC2=CC3=C(C=C2)C=NC=C3 |
Solubility-In vitro: | DMSO: 51 mg/mL (170.95 mM) Water: Insoluble Ethanol: Warmed: 51 mg/mL (170.95 mM) * <1 mg/ml means slightly soluble or insoluble. |
Target Info
PRMT3: | 31 nM |
PRMT3: | 53 nM(Kd) |
Storage
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Preparing Stock Solutions
0.1 mM_1 mg: 33.52 mL
0.1 mM_5 mg: 167.62 mL
0.1 mM_10 mg: 335.23 mL
0.5 mM_1 mg: 6.7 mL
0.5 mM_5 mg: 33.52 mL
0.5 mM_10 mg: 67.05 mL
1 mM_1 mg: 3.35 mL
1 mM_5 mg: 16.76 mL
1 mM_10 mg: 33.52 mL
5 mM_1 mg: 0.67 mL
5 mM_5 mg: 3.35 mL
5 mM_10 mg: 6.7 mL
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