Tiplaxtinin (PAI-039)

Product Name:	Tiplaxtinin (PAI-039)
CAT#:	DMP-2312-LGZ-1
Package:	5mg/10mg/25mg
Datasheet

Description

Tiplaxtinin is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1), its IC50 value is 2.7 μM.

Basic Information

Synonyms:	PAI-039
Application:	PAI-1 Inhibitor
CAS Number:	393105-53-8
Formula:	C24H16F3NO4
Molecular Weight:	439.3833
SMILES:	C1=CC=C(C=C1)CN2C=C(C3=C2C=CC(=C3)C4=CC=C(C=C4)OC(F)(F)F)C(=O)C(=O)O
*Solubility-In vitro:*	In vitro (25°C): DMSO: 62 mg/mL (141.1 mM) Water: Insoluble Ethanol: Warmed: 15 mg/mL (34.13 mM)
*Solubility-In vivo:*	2.0% Tween 80+0.5% methylcellulose: 28 mg/mL

Target Info

PAI-1:

2.7 μM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 22.76 mL 0.1 mM_5 mg: 113.8 mL 0.1 mM_10 mg: 227.59 mL 0.5 mM_1 mg: 4.55 mL 0.5 mM_5 mg: 22.76 mL 0.5 mM_10 mg: 45.52 mL 1 mM_1 mg: 2.28 mL 1 mM_5 mg: 11.38 mL 1 mM_10 mg: 22.76 mL 5 mM_1 mg: 0.46 mL 5 mM_5 mg: 2.28 mL 5 mM_10 mg: 4.55 mL

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