Inquiry
(±)-Verapamil Hydrochloride (USP Grade)
| Product Name: |
(±)-Verapamil Hydrochloride (USP Grade) |
| CAT#: |
DMCS-2401-LGZ-9 |
| Package: |
100 mg; 1 g; 5 g |
| Datasheet |
|
Description
Alpha1 adrenergic receptor (α-AR) antagonist.
A typical calcium channel protein inhibitor that blocks L-type Ca2+ channels in smooth muscle cells and cardiomyocytes.
Vasodilators known to reduce the renal clearance of digoxin and are used to control hypertension, angina, cardiac arrhythmias, and vascular headaches.
In vitro apoptosis inducers in primary and metastatic colon adenocarcinoma cell lines
Inhibitors of drug efflux pump proteins, such as Mdr (p-glycoprotein), are often overexpressed in certain tumor cell lines.
Substrate of CYP3A4 and CYP2C6.
Used for fluorescent cell sorting of DNA content because it blocks the efflux of a variety of DNA-binding fluorescent carriers such as Hoechst 33342.
Anti-diabetic in animal models by limiting the expression of TXNIP.
Basic Information
| CAS Number: |
152-11-4 |
| Formula: |
C27H38N2O4. HCl |
| Molecular Weight: |
454.6. 36.5 |
| Synonyms: |
NSC135784; NSC272366; NSC657799 |
| InChi Key: |
DOQPXTMNIUCOSY-UHFFFAOYSA-N |
| Appearance: |
White powder |
| Purity Chemicals: |
≥99% (NMR) |
| SMILES: |
[Cl-].COC1=C(OC)C=C(CC[NH+](C)CCCC(C#N)(C(C)C)C2=CC(OC)=C(OC)C=C2)C=C1 |
| Solubility: |
Soluble in methanol (50 mg/ml), ethanol or water. |
| Source/Host Chemicals: |
Synthetic. |
Shipping and Handling
| Storage (Short Term): |
4°C |
| Storage (Long Term): |
4°C |
| Shipping: |
Ambient |
| Handling Advice: |
Protect from moisture and light. Keep cool and dry. |
| Stability: |
When stored at a temperature of +4°C, it remains stable for at least 2 years. |
All of our services and products are intended for
preclinical research use only and cannot be used to diagnose, treat or manage patients.
-Verapamil Hydrochloride (USP Grade) .png.png)
