YF-2

Product Name:	YF-2
CAT#:	DEHA-2312-LGZ-10
Package:	5mg/10mg/50mg/100mg
Datasheet

Description

YF-2 is a highly selective histone acetyltransferase activator that can pass through the blood-brain barrier. It can acetylate H3 in the hippocampus and can be used to fight cancer and Alzheimer's disease. The ec50s for CBP, PCAF and GCN5 are 2.75 μM, 29.04 μM and 49.31 μM respectively, but have no effect on HDAC.

Basic Information

Synonyms:	YF2; YF 2
Application:	Histone Acetyltransferase Activator
CAS Number:	1311423-89-8
Formula:	C20H22ClF3N2O3
Molecular Weight:	430.85
SMILES:	O=C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)C2=C(OCC)C=CC=C2OCCN(C)C
*Solubility-In vitro:*	DMSO: 78 mg/mL (181.03 mM) Water: 78 mg/mL (181.03 mM) Ethanol: 78 mg/mL (181.03 mM) * <1 mg/ml means slightly soluble or insoluble.

Target Info

GCN5:	49.31 μM (EC50)
GCN5/PCAF:	29.04 μM (EC50)
CBP:	2.75μM (EC50)

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 23.21 mL 0.1 mM_5 mg: 116.05 mL 0.1 mM_10 mg: 232.1 mL 0.5 mM_1 mg: 4.64 mL 0.5 mM_5 mg: 23.21 mL 0.5 mM_10 mg: 46.42 mL 1 mM_1 mg: 2.32 mL 1 mM_5 mg: 11.6 mL 1 mM_10 mg: 23.21 mL 5 mM_1 mg: 0.46 mL 5 mM_5 mg: 2.32 mL 5 mM_10 mg: 4.64 mL

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