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Letaxaban (TAK-442)

Description

Letaxaban is a highly effective, selective, and orally active factor Xa inhibitor, which is a tetrahydropyrimidin-2(1H)-one derivative. It inhibited endogenous FXa activity in platelet-poor human [half-maximal inhibitory concentration (IC(50)): 53 nM, TAK-442] and rat (IC(50): 32 nM, TAK-442) plasma.

Basic Information

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment. In lyophilized form, the chemical remains stable for 36 months. In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

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